Research on core strength training for volleyball players / Pesquisa sobre o treinamento do core dos jogadores de voleibol / Investigación sobre el entrenamiento del core de los jugadores de voleibol

ABSTRACT Introduction: Modern exercise physiology theory states that abdominal core muscle strength plays a very important role in the completion of athletes' motor skills; the specific performance is to stabilize the athlete's center of gravity, the source of explosion and power transmission beyond his center of control. Objective: Verify the effect of an experimental training methods on the muscular strength of the abdominal core in volleyball athletes. Methods: 24 athletes were divided into an experimental group and a control group, in order to ensure that the baseline indicators of the two groups before the experiment did not show significant comparison, using independent sample t-test and paired sample t-test. Results: The average number of sit-ups of the two groups of students was 58.15 and 70.52n, respectively, the five baseline indicators of stability of the two groups were all significant, and the strength training methods in the experimental group were better than those in the control group. Conclusion: The presented experimental method helps to improve the success rate in athlete's jump. The core strength training methods used in the experimental group in jumping were superior to the traditional training methods used in the control group. Level of Evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: A moderna teoria da fisiologia do exercício afirma que a força muscular do core desempenha um papel muito importante na conclusão das habilidades motoras dos atletas; o desempenho específico é estabilizar o centro de gravidade do atleta, a fonte de explosão e transmissão de potência além do seu centro de controle. Objetivo: Verificar o efeito dos métodos de um treinamento experimental sobre a força muscular do core em atletas de voleibol. Métodos: 24 atletas foram divididos em grupo experimental e grupo de controle, a fim de garantir que os indicadores basais dos dois grupos antes do experimento não apresentassem comparação significativa, usando teste t de amostra independente e teste t de amostra pareada. Resultados: O número médio de sit-ups dos dois grupos de estudantes foi de 58,15 e 70,52n, respectivamente, os cinco indicadores básicos de estabilidade dos dois grupos foram todos significativos, e os métodos de treinamento da força no grupo experimental foram melhores do que os do grupo controle. Conclusão: O método experimental apresentada ajuda a melhorar a taxa de sucesso no salto do atleta. Os métodos de treinamento da força do core usados no grupo experimental em salto foram superiores aos métodos tradicionais de treinamento usados no grupo de controle. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: La teoría moderna de la fisiología del ejercicio afirma que la fuerza muscular del core desempeña un papel muy importante en la realización de las habilidades motrices de los atletas; la actuación específica consiste en estabilizar el centro de gravedad del atleta, la fuente de explosión y la transmisión de potencia más allá de su centro de control. Objetivo: Verificar el efecto de los métodos de un entrenamiento experimental sobre la fuerza muscular del core en atletas de voleibol. Métodos: 24 atletas fueron divididos en un grupo experimental y un grupo de control, con el fin de garantizar que los indicadores basales de los dos grupos antes del experimento no mostraran una comparación significativa, utilizando la prueba t de muestras independientes y la prueba t de muestras emparejadas. Resultados: El número medio de sentadillas de los dos grupos de estudiantes fue de 58,15 y 70,52n, respectivamente, los cinco indicadores de estabilidad de referencia de los dos grupos fueron todos significativos, y los métodos de entrenamiento de fuerza del grupo experimental fueron mejores que los del grupo de control. Conclusión: El método experimental presentado ayuda a mejorar la tasa de éxito en el salto del atleta. Los métodos de entrenamiento del core utilizados en el grupo experimental en los saltos fueron superiores a los métodos de entrenamiento tradicionales utilizados en el grupo de control. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Effects of vitamin C on reversing cisplatin resistance in oral squamous cell carcinoma / 中国肿瘤生物治疗杂志

@#Objective: To study the effects of vitamin C (VC) on reversing cisplatin (DDP) resistance in oral squamous cell carcinoma (OSCC) and the mechanism. Methods: Human OSCC CAL27 cells were cultured in vitro and DDP-resistant CAL27 cell line (CAL27/ DDP) was screened by increasing concentration gradient method. Plate clone formation assay, CCK-8, Wound healing assay, Annexin V-FITC/PI staining flow cytometry were used to determine the effects of DDP alone or in combination with VC on colony formation, proliferation, migration and apoptosis of CAL27/DDP cells. Western blotting was used to detect the expression level of P-gp protein in CAL27 cells, CAL27/DDP cells and VC treated CAL27/DDP cells. Results: The inhibition concentration (IC50) of DDP increased significantly in CAL27/DDP cells as compared with that in CAL27 cells (P<0.05), indicating CAL27/DDP was DDP-resistant.After the combination with VC, the IC50 of DDP on CAL27/DDP cells was significantly reduced compared with that of DDP alone (P<0.05). DDP combined with VC significantly inhibited the migration of CAL27/DDP cells (P<0.01), and promoted the apoptosis rate (P<0.01). The expression level of P-gp protein in CAL27/DDP cells was increased compared with that in CAL27 cells (P<0.05), but decreased after VC intervention (P<0.05). Conclusion: VC can reverse DDP-resistance in OSCC cells by inhibiting P-gp protein expression.

Advances in molecular mechanisms of platinum drug resistance in oral squamous cell carcinoma / 中国肿瘤生物治疗杂志

@#口腔鳞状细胞癌是头颈部常见的恶性肿瘤，化疗是其常规治疗手段之一，铂类化疗药物作为一线化疗药物应用于口 腔鳞状细胞癌的治疗中。然而化疗耐药极大地限制了铂类化疗药物的临床应用，因此阐明口腔鳞状细胞癌铂类化疗耐药的分子 机制具有十分重要的临床意义。本文从药物转运蛋白、DNA损伤修复、细胞凋亡、自噬、上皮间质转化和miRNA等方面综述了口 腔鳞状细胞癌铂类化疗耐药的分子机制，以期为逆转铂类耐药及相关肿瘤的生物治疗靶点的开发提供新的思路。

DNA methylation modulates H19 and IGF2 expression in porcine female eye

Abstract The sexually dimorphic expression of H19/IGF2 is evolutionarily conserved. To investigate whether the expression of H19/IGF2 in the female porcine eye is sex-dependent, gene expression and methylation status were evaluated using quantitative real-time PCR (qPCR) and bisulfite sequencing PCR (BSP). We hypothesized that H19/IGF2 might exhibit a different DNA methylation status in the female eye. In order to evaluate our hypothesis, parthenogenetic (PA) cells were used for analysis by qPCR and BSP. Our results showed that H19 and IGF2 were over-expressed in the female eye compared with the male eye (3-fold and 2-fold, respectively). We observed a normal monoallelic methylation pattern for H19 differentially methylated regions (DMRs). Compared with H19 DMRs, IGF2 DMRs showed a different methylation pattern in the eye. Taken together, these results suggest that elevated expression of H19/IGF2 is caused by a specific chromatin structure that is regulated by the DNA methylation status of IGF2 DMRs in the female eye.

Coronary Heart Disease and Biomarkers and Its Clinical Application.

Cardiovascular disease is a major health concern globally. Genetic testing is an attractive tool for cardiovascular disease prediction because it is a low-cost, high-fidelity technology with multiplex capability. Developments in genomic discovery have yielded valuable new candidates in the quest for better biomarkers and novel therapeutic targets. This brief review focuses on recent trends in biomarkers of cardiovascular disease. DNA microarrays, single nucleotide polymorphism chips, linkage analysis, genome-wide association studies, and other strategies have increased our knowledge of metabolic diseases of the heart. This review also examines the potential applications and challenges of using genetic information for predicting cardiovascular disease.